Endocrine Abstracts

Emerging studies suggest that GPCR oligomerization could confer functional advantages to receptors and even constitute clinical applications. Recent study found that angiotensin II 1a receptors (AT1aR) and secretin receptors (SCTR) can form heteromer and participate in osmoregulation. Studying GPCR dimerization faces many technical challenges, including selectivity and specificity. Since transmembrane (TM) peptides can act as competitors against the interacting surfaces betwee...